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Endocrinology and Diabetes

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Research

In conjunction with the Albert Einstein College of Medicine, the Division of Endocrinology and Diabetes at CHAM participates in a wide range of research from basic science to human clinical trials.

The Division of Endocrinology and Diabetes at CHAM participates in a wide range of research from basic science to human clinical trials In conjunction with Albert Einstein College of Medicine.

Our research includes conducting trials for newly diagnosed diabetes patients and those living with type 1 or type 2 diabetes, polycystic ovarian syndrome or obesity, as well as screening for relatives of type 1 diabetics and much more. We are currently focused on research to:  

Improve the Quality of Life for Children with Diabetes

Through research using the artificial pancreas and drug therapy, CHAM endocrinologists are working to automate mealtime glucose measurement and insulin delivery, and reduce sugar levels in type 1 diabetics. Patients in the current study have not had to worry about frequent glucose checks, and blood sugars remain under control.

Create Better Outcomes for Girls with Turner Syndrome

As a destination of choice for girls born with Turner syndrome, and their families, CHAM’s experts draw upon the hospital’s vast resources—including infertility treatment, diabetes and thyroid management, and orthopaedic surgery—to treat the many health concerns that these patients encounter. CHAM has also partnered with the Turner Syndrome Foundation to host in-depth educational seminars each year.

Discover Alternative Approaches to Nutritional Counseling

Endocrinologists and nutritionists at CHAM are studying whether nutrition and weight-loss counseling provided in a group setting is equally or more beneficial than a one-on-one approach. Each session offers patients and their parents the opportunity to ask questions and interact with other families, thereby building a lasting network of support and providing an effective means through which lower-income families can achieve their health goals.

Prepare for Diabetes Care During Disaster

By surveying patients in the months after Hurricane Sandy, CHAM endocrinologists determined that patients in lower socioeconomic brackets were equally prepared as those who are more affluent for general disasters and diabetes management. These findings differ from results of an earlier survey conducted in Texas and serve to guide CHAM’s future educational efforts.
Research is a great way to get involved, learn more about diabetes, be more involved in your care and help others. 

You can use the information below to learn more about some of our trials.

Active Clinical Trials

Trial Description
Disease / Condition
Principal Investigator
Contact
Trial DescriptionA Bilingual Virtually-based Intervention (PEDALL) for the Prevention of Weight Gain in Childhood ALL Patients Considering Key Genetic and Sociodemographic Risk Factors - Acute lymphoblastic leukemia (ALL) has been referred to as a "pre-obese state", with many studies describing the onset of obesity during treatment. Weight gain typically begins within the first month of ALL diagnosis, stabilizes, and then resumes at the beginning of maintenance and continues into survivorship. Children and adolescents with healthy weight at diagnosis are the most vulnerable to weight gain; up to 70% develop overweight/obesity (OW/OB) by the end of treatment (EOT). Weight gain during treatment is one of the most consistently reported risk factors for weight gain in survivorship and is associated with an increased odds of being OW/OB 5-years post-EOT. Significant clinical ramifications are associated with being OW/OB. A meta-analysis led by the Children's Oncology Group nutrition committee found that OW/OB is associated with a 31% increased risk of mortality in ALL. The objective of the study team is to prevent the development of OW/OB during maintenance chemotherapy using a six-month virtually delivered dietary education intervention (PEDALL) in English and Spanish speaking families of children and adolescents undergoing treatment for ALL. Once enrolled, subjects will be randomized to PEDALL or standard of care (SOC). Subjects in the PEDALL group will receive 26 contact hours of specialized nutrition education and counseling via a virtual platform. The purpose of this study is to determine the effectiveness of a virtually-delivered dietary education intervention in the prevention of OW/OB compared to SOC during maintenance chemotherapy. The clinical impact of this study will improve the understanding of pre-treatment factors predictive of the efficacy of intervention to prevent unhealthy weight gain among patients treated for ALL. Study findings may lead to the allocation of limited clinical resources to individuals most susceptible to OW/OB. Information obtained from this study may also direct the refinement of counseling techniques to enhance the likelihood of success over the course of treatment for ALL and into survivorship. The long-term goal is to enhance the likelihood of success of weight maintenance during therapy thereby mitigating excess toxicities during treatment and reducing nutrition-related late-effects associated with OW/OB among survivors of childhood ALL.NCT05963971
Disease/ConditionAcute Lymphoblastic Leukemia
Obesity
Principal InvestigatorLisa Gennarini
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