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<div class="HwContainer HwElement" id="HwContainer"><a class="HwMainSkipNavigation" href="#HwContentTitle"><span class="HwAccessibilityText">Skip Navigation</span></a><div class="HwBlock" id="HwMain" role="main"><div class="HwRow"><div class="HwColumn" id="HwColumnSidebar1"><div class="HwCustom" id="HwCustomSidebar"> </div></div><div class="HwColumn" id="HwColumnContent"><div id="HwContentTop"> </div><div class="HwTypeMedicalTest HwContentWrapper HwElement" role="article" id="HwContentWrapper"><div class="HwCustom" id="HwCustomContentTop"> </div><div class="HwContentHeader"><p><a name="top" id="Hwtop"><span class="HwAccessibilityText">Top of the page</span></a> </p></div><div class="HwContentTitle"><h1 id="HwContentTitle" tabindex="-1">Estrogen Test</h1></div><div class="HwContentTopNavigation"> </div><div class="HwContent"><div class="HwNavigationSection HwSectionSpecialSection" id="sec-hw6203"><h2 class="HwSectionTitle" fingerprint="d4032d6d" fingerprint-exact="4fcae40e">Test Overview</h2> <p fingerprint="21f6d0db" fingerprint-exact="d34a05a6">An estrogen test measures the level of the most important estrogen <a class="HwLinkDefinition" data-hw-type="Definition" data-hw-document-href="sth149942" data-hw-section="sth149942-sec" rel="Definition" hw:document-type="Definition" hw:document-href="sth149942" data-hwid="sth149942" hw:section-href="sth149942-sec" href="?id=sth149942#sth149942-sec"><span class="HwLinkText">hormones</span></a> in a blood or urine sample. It measures estradiol, estriol, and estrone. </p> <div class="HwOptionalAll"> <ul fingerprint="d8cf324c" fingerprint-exact="dfd9e754"> <li class="HwOptionalAny">Estradiol is the most common type of estrogen measured for nonpregnant women. The amount of estradiol in a woman's blood varies throughout her <a class="HwLinkDefinition" data-hw-type="Definition" data-hw-document-href="stm159394" data-hw-section="stm159394-sec" rel="Definition" hw:document-type="Definition" hw:document-href="stm159394" data-hwid="stm159394" hw:section-href="stm159394-sec" href="?id=stm159394#stm159394-sec"><span class="HwLinkText">menstrual cycle</span></a>. After <a class="HwLinkDefinition" data-hw-type="Definition" data-hw-document-href="stm159386" data-hw-section="stm159386-sec" rel="Definition" hw:document-type="Definition" hw:document-href="stm159386" data-hwid="stm159386" hw:section-href="stm159386-sec" href="?id=stm159386#stm159386-sec"><span class="HwLinkText">menopause</span></a>, it drops to a very low but constant level. </li> </ul> </div> <div class="HwOptionalAll"> <ul fingerprint="ec1c0154" fingerprint-exact="7493f58d"> <li class="HwOptionalAny">Estriol levels are most often measured only during pregnancy. Estriol is produced in large amounts by the <a class="HwLinkDefinition" data-hw-type="Definition" data-hw-document-href="stp1633" data-hw-section="stp1633-sec" rel="Definition" hw:document-type="Definition" hw:document-href="stp1633" data-hwid="stp1633" hw:section-href="stp1633-sec" href="?id=stp1633#stp1633-sec"><span class="HwLinkText">placenta</span></a>. This is the tissue that links the fetus to the mother. Estriol can be found as early as the 9th week of pregnancy. The levels keep rising until delivery. Estriol can also be measured in urine. </li> </ul> </div> <div class="HwOptionalAll"> <ul fingerprint="9c1e3d4f" fingerprint-exact="50c6f592"> <li class="HwOptionalAny">Estrone may be measured in women who have gone through menopause. It's done to find out their estrogen levels. It also may be measured in men or women who might have cancer of the <a class="HwLinkMultiMedia" data-hw-type="MultiMedia" data-hw-document-href="zm6366" data-hw-section="zm6366-sec" rel="MultiMedia" hw:document-type="MultiMedia" hw:document-href="zm6366" data-hwid="zm6366" hw:section-href="zm6366-sec" hw:link-type="image" href="?id=zm6366#zm6366-sec"><span class="HwLinkText">ovaries</span></a>, <a class="HwLinkMultiMedia" data-hw-type="MultiMedia" data-hw-document-href="tp10317" data-hw-section="tp10317-sec" rel="MultiMedia" hw:document-type="MultiMedia" hw:document-href="tp10317" data-hwid="tp10317" hw:section-href="tp10317-sec" hw:link-type="image" href="?id=tp10317#tp10317-sec"><span class="HwLinkText">testicles</span></a>, or <a class="HwLinkMultiMedia" data-hw-type="MultiMedia" data-hw-document-href="tp10125" data-hw-section="tp10125-sec" rel="MultiMedia" hw:document-type="MultiMedia" hw:document-href="tp10125" data-hwid="tp10125" hw:section-href="tp10125-sec" hw:link-type="image" href="?id=tp10125#tp10125-sec"><span class="HwLinkText">adrenal glands</span></a>. </li> </ul> </div> <p fingerprint="ff154d9c" fingerprint-exact="4a349c2f">Both men and women make estrogen hormones. Estrogens are responsible for female sexual development and function, such as breast development and the menstrual cycle. In women, estrogens are made mainly in the ovaries and in the placenta during pregnancy. Small amounts are also made by the adrenal glands. In men, small amounts of estrogens are made by the adrenal glands and testicles. </p> <p fingerprint="89c66aa7" fingerprint-exact="2958955f">Small amounts of estrone are made throughout the body in most tissues, especially fat and muscle. This is the major source of estrogen in women who have gone through menopause. </p> <p fingerprint="2c4a7ee8" fingerprint-exact="9d0faf90">For pregnant women, the level of estriol in the blood is used in a serum quad screening test. In most cases, this test is done between 15 and 22 weeks of pregnancy. It checks the levels of four substances in a pregnant woman's blood. They are the hormone inhibin A, alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), and a type of estrogen (unconjugated estriol, or uE3). The levels of these substances—along with a woman's age and other factors—help the doctor figure out the chance that the baby may have certain problems or birth defects. </p> </div><div class="HwNavigationSection HwSectionSpecialSection" id="sec-hw6204"><h2 class="HwSectionTitle" fingerprint="3d5095ef" fingerprint-exact="55cd7304">Why It Is Done</h2> <p fingerprint="ef3ce49f" fingerprint-exact="d6cd62c9">A test for estrogen is done to:</p> <ul fingerprint="317cd7de" fingerprint-exact="2dac8861"> <li>Help find fetal birth defects (especially <a class="HwLinkDefinition" data-hw-type="Definition" data-hw-document-href="std120885" data-hw-section="std120885-sec" rel="Definition" hw:document-type="Definition" hw:document-href="std120885" data-hwid="std120885" hw:section-href="std120885-sec" href="?id=std120885#std120885-sec"><span class="HwLinkText">Down syndrome</span></a>) during pregnancy. When the test for estriol is done with hormone inhibin A, alpha-fetoprotein (AFP), and human chorionic gonadotropin (hCG), it is called a quad screen test. Other blood tests and fetal ultrasound may be done as well.</li> <li>Check for estrogen-producing tumors of the ovaries in girls before menstruation starts and in women after menopause.</li> <li>Help explain enlargement of breast tissue in men (gynecomastia). This test can also help find out if there are estrogen-producing tumors growing in the testicles.</li> <li>Monitor treatment with fertility medicines.</li> </ul> </div><div class="HwNavigationSection HwSectionSpecialSection" id="sec-hw6205"><h2 class="HwSectionTitle" fingerprint="026e985e" fingerprint-exact="df1d0bbc">How To Prepare</h2> <p fingerprint="3bdc5032" fingerprint-exact="3ea00523">You do not need to do anything special to prepare for this test. </p> </div><div class="HwNavigationSection HwSectionSpecialSection" id="sec-hw95818"><h2 class="HwSectionTitle" fingerprint="e59ce77f" fingerprint-exact="42dd83e2">How It Is Done</h2> <p fingerprint="bca56b1a" fingerprint-exact="7c629469">A health professional uses a needle to take a blood sample, usually from an arm.</p> <h3 class="HwSubSectionTitle" fingerprint="ffd3beac" fingerprint-exact="500b4a26">Watch</h3> <div class="HwOptionalAll"> <div class="hwMediaLinks"> <ul fingerprint="2a924914" fingerprint-exact="939aff65"> <li class="HwOptionalAny"> <a class="HwLinkMultiMedia" data-hw-type="MultiMedia" data-hw-document-href="acj1944" data-hw-section="acj1944-sec" rel="MultiMedia" hw:document-type="MultiMedia" hw:document-href="acj1944" data-hwid="acj1944" hw:section-href="acj1944-sec" hw:link-type="video" href="?id=acj1944#acj1944-sec"><span class="HwLinkText">Learning About Your Blood Test</span><br><img class="HwMediaImage" data-hw-resource-path="media/thumbnails/acj1944_416x312.jpg" hw:resource-path="media/thumbnails/acj1944_416x312.jpg" src="https://ixbapi.healthwise.net/Resource/14.3/en-us/media/thumbnails/acj1944_416x312.jpg" width="416" height="312" alt hw:release-quarter="14.3"></a> </li> <li class="HwOptionalAny"> <a class="HwLinkMultiMedia" data-hw-type="MultiMedia" data-hw-document-href="aci5157" data-hw-section="aci5157-sec" rel="MultiMedia" hw:document-type="MultiMedia" hw:document-href="aci5157" data-hwid="aci5157" hw:section-href="aci5157-sec" hw:link-type="video" href="?id=aci5157#aci5157-sec"><span class="HwLinkText">Learning About Blood Tests for Children</span><br><img class="HwMediaImage" data-hw-resource-path="media/thumbnails/aci5157_416x312.jpg" hw:resource-path="media/thumbnails/aci5157_416x312.jpg" src="https://ixbapi.healthwise.net/Resource/14.3/en-us/media/thumbnails/aci5157_416x312.jpg" width="416" height="312" alt hw:release-quarter="14.3"></a> </li> </ul> </div> </div> </div><div class="HwNavigationSection HwSectionSpecialSection" id="sec-hw95823"><h2 class="HwSectionTitle" fingerprint="2dd5db50" fingerprint-exact="deba34d5">How It Feels</h2> <p fingerprint="1ac94c75" fingerprint-exact="5d3995d8">When a blood sample is taken, you may feel nothing at all from the needle. Or you might feel a quick sting or pinch.</p> </div><div class="HwNavigationSection HwSectionSpecialSection" id="sec-hw95825"><h2 class="HwSectionTitle" fingerprint="a566bce5" fingerprint-exact="1aacb8d8">Risks</h2> <p fingerprint="f81952f3" fingerprint-exact="73b0e5b4">There is very little chance of having a problem from this test. When a blood sample is taken, a small bruise may form at the site.</p> </div><div class="HwNavigationSection HwSectionSpecialSection" id="sec-hw6209"><h2 class="HwSectionTitle" fingerprint="9413e669" fingerprint-exact="9fa3e414">Results</h2> <p fingerprint="2563156d" fingerprint-exact="7e480615">Results are usually available within 24 hours. </p> <h3 class="HwSubSectionTitle" fingerprint="7d152b4d" fingerprint-exact="218568e4">Normal</h3> <p fingerprint="75a53eba" fingerprint-exact="d93c923c">For girls and women between puberty and menopause, estrogen levels vary throughout the <a class="HwLinkDefinition" data-hw-type="Definition" data-hw-document-href="stm159394" data-hw-section="stm159394-sec" rel="Definition" hw:document-type="Definition" hw:document-href="stm159394" data-hwid="stm159394" hw:section-href="stm159394-sec" href="?id=stm159394#stm159394-sec"><span class="HwLinkText">menstrual cycle</span></a>. </p> <p fingerprint="22049f10" fingerprint-exact="465acd27">Each lab has a different range for what's normal. Your lab report should show the range that your lab uses for each test. The normal range is just a guide. Your doctor will also look at your results based on your age, health, and other factors. A value that isn't in the normal range may still be normal for you.</p> <p fingerprint="1f08c9d3" fingerprint-exact="db0cffe8">Many conditions can change estrogen levels. Your doctor will talk with you about any important abnormal results as they relate to your symptoms and past health. </p> <h3 class="HwSubSectionTitle" fingerprint="43ad997f" fingerprint-exact="38685d68">High values</h3> <p fingerprint="8c3573f6" fingerprint-exact="2ec4a9f4">High values may be caused by: </p> <ul fingerprint="2eb5dea0" fingerprint-exact="b5907fee"> <li>Ovarian stimulation used to treat infertility (for example, before <a class="HwLinkDefinition" data-hw-type="Definition" data-hw-document-href="tn5407" data-hw-section="tn5407-sec" rel="Definition" hw:document-type="Definition" hw:document-href="tn5407" data-hwid="tn5407" hw:section-href="tn5407-sec" href="?id=tn5407#tn5407-sec"><span class="HwLinkText">in vitro fertilization</span></a>). </li> <li>Cancer, such as cancer of the <a class="HwLinkMultiMedia" data-hw-type="MultiMedia" data-hw-document-href="zm6366" data-hw-section="zm6366-sec" rel="MultiMedia" hw:document-type="MultiMedia" hw:document-href="zm6366" data-hwid="zm6366" hw:section-href="zm6366-sec" hw:link-type="image" href="?id=zm6366#zm6366-sec"><span class="HwLinkText">ovaries</span></a>, <a class="HwLinkMultiMedia" data-hw-type="MultiMedia" data-hw-document-href="tp10317" data-hw-section="tp10317-sec" rel="MultiMedia" hw:document-type="MultiMedia" hw:document-href="tp10317" data-hwid="tp10317" hw:section-href="tp10317-sec" hw:link-type="image" href="?id=tp10317#tp10317-sec"><span class="HwLinkText">testicles</span></a>, or <a class="HwLinkMultiMedia" data-hw-type="MultiMedia" data-hw-document-href="tp10125" data-hw-section="tp10125-sec" rel="MultiMedia" hw:document-type="MultiMedia" hw:document-href="tp10125" data-hwid="tp10125" hw:section-href="tp10125-sec" hw:link-type="image" href="?id=tp10125#tp10125-sec"><span class="HwLinkText">adrenal glands</span></a>. </li> <li>Serious liver disease (<a class="HwLinkDefinition" data-hw-type="Definition" data-hw-document-href="stc123718" data-hw-section="stc123718-sec" rel="Definition" hw:document-type="Definition" hw:document-href="stc123718" data-hwid="stc123718" hw:section-href="stc123718-sec" href="?id=stc123718#stc123718-sec"><span class="HwLinkText">cirrhosis</span></a>). </li> <li>A pregnancy with more than one fetus, such as twins or triplets. </li> <li>Early puberty. </li> </ul> <h3 class="HwSubSectionTitle" fingerprint="01f76001" fingerprint-exact="f73fd7e9">Low values</h3> <p fingerprint="155d857a" fingerprint-exact="d03f8f64">Low values may be caused by: </p> <ul fingerprint="a385ffd6" fingerprint-exact="d0a87a52"> <li>Problems with ovarian function. This can be caused by a failure of an ovary to develop properly (<a class="HwLinkDefinition" data-hw-type="Definition" data-hw-document-href="stt11671" data-hw-section="stt11671-sec" rel="Definition" hw:document-type="Definition" hw:document-href="stt11671" data-hwid="stt11671" hw:section-href="stt11671-sec" href="?id=stt11671#stt11671-sec"><span class="HwLinkText">Turner's syndrome</span></a>) or because of a drop in <a class="HwLinkDefinition" data-hw-type="Definition" data-hw-document-href="stp1652" data-hw-section="stp1652-sec" rel="Definition" hw:document-type="Definition" hw:document-href="stp1652" data-hwid="stp1652" hw:section-href="stp1652-sec" href="?id=stp1652#stp1652-sec"><span class="HwLinkText">pituitary gland</span></a> activity. </li> <li> <a class="HwLinkDefinition" data-hw-type="Definition" data-hw-document-href="sta123232" data-hw-section="sta123232-sec" rel="Definition" hw:document-type="Definition" hw:document-href="sta123232" data-hwid="sta123232" hw:section-href="sta123232-sec" href="?id=sta123232#sta123232-sec"><span class="HwLinkText">Anorexia nervosa</span></a>. </li> <li>Menopause. </li> <li>A problem with the fetus or placenta during pregnancy. </li> </ul> </div><div class="HwNavigationSection HwSectionRelatedInformation" id="sec-hw6200-RelInfo"><h2 class="HwSectionTitle" fingerprint="d5f858e0" fingerprint-exact="c0ffe04b">Related Information</h2><ul fingerprint="c33987e5" fingerprint-exact="f02c2f97"><li class="HwOptionalAny"><a data-hw-type="Focus" data-hw-document-href="zm2257" data-hw-section="zm2257-sec" hw:document-type="Focus" hw:document-href="zm2257" data-hwid="zm2257" hw:section-href="zm2257-sec" href="?id=zm2257#zm2257-sec">Medical Tests: Questions to Ask the Doctor</a></li><li class="HwOptionalAny"><a data-hw-type="MedicalTest" data-hw-document-href="ta7038" data-hw-section="acl4085" hw:document-type="MedicalTest" hw:document-href="ta7038" data-hwid="ta7038" hw:section-href="acl4085" href="?id=ta7038#acl4085">Quad Screening for Birth Defects</a></li></ul></div><div class="HwNavigationSection HwCreditsSection HwSectionCredits" id="sec-hw6200-Credits"><h2 class="HwSectionTitle">Credits</h2><div class="HwContentInformation"><div class="HwLastUpdated"><p><span class="HwInfoLabel">Current as of: </span> April 30, 2024</p></div><div class="HwCredits"><p><span class="HwInfoLabel">Author: </span><a class="HwLinkExternal" href="https://www.healthwise.org/specialpages/legal/abouthw/en" title="Opens in a new window"><span class="HwLinkText">Ignite Healthwise, LLC Staff</span></a><br><span><b><a class="HwLinkExternal" href="https://www.healthwise.org/specialpages/legal/abouthw/en" title="Opens in a new window"><span class="HwLinkText">Clinical Review Board</span></a></b></span><br>All Healthwise education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.</p></div></div></div></div><div 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